Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[ n]urilsArticle Published on 2022-10-142022-11-15 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 치료제, [키워드] acting amino acids Antiviral Antiviral compound Antiviral effect antivirals Cell Compound compounds Contact cucurbituril disease dose−response Efficacy Extracellular herpes simplex homologue Interaction investigated macrocycle mechanism morbidity Mortality nontoxic pathogen property Protein respiratory syncytial virus responsible RSV SARS-CoV-2 viral surface virucidal virus viruses virustatic. [DOI] 10.1021/acsinfecdis.2c00186 PMC 바로가기
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article
Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severityArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] 바이오마커, 변종, [키워드] Amino acid amino acids analysed Analysis C-reactive protein Clinical diagnosis Clinical severity clinical suspicion Clinical tests collected COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Diagnosis diagnostic Disease progression driver dysregulation eliminating expand exploratory feature Health hospital hospitalised patient likelihood marker metabolomics Metadata Non-invasive offer outcomes Patient patients peripheral oxygen saturation Prognosis progressed receiver operating characteristics recent Research reservoir respiratory rate resulting reveal RT-PCR testing Saliva saliva sample serum severity shown the disease Treatment Vaccine variants [DOI] 10.1371/journal.pone.0274967 PMC 바로가기
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR)Droplet Digital PCR(RT-ddPCR)을 사용한 SARS-CoV-2 Omicron 변이체의 빠르고 정확한 식별Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Allelic discrimination amino acids B.1.1.529 B.1.1.529. Clinical treatment clinician Concentration confounding factor Delta described develop digital PCR Efficacy Frequency genome sequence Genome sequences genotyping identify Laboratory medium Mutation mutations NGS omicron Omicron variants positive Prevalence primer probe sequences problem professionals Protein public health Rapid reaction Receptor binding domain respiratory viruses RNA robust S-gene SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants Sensitivity and specificity shifting specimen spike Spike protein state substantial reduction substantial reductions susceptibility tested the SARS-CoV-2 therapy Transmission Transport transport medium Vaccine vaccine efficacy variant variants Variation Washington [DOI] 10.1016/j.jcv.2022.105218 PMC 바로가기 [Article Type] Article
Serum metabolomic abnormalities in survivors of non-severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Heliyon [Category] 바이오마커, [키워드] abnormality amino acids approaches association Biomarker Care changes in characteristic consequence COVID-19 COVID-19 survivors discharge Fatty acid Health Health consequences Health status highlight Host identify Infection Inflammatory responses information Intervention Kynurenine pathway lipid metabolism Liver injury mental health metabolic metabolic abnormalities Metabolic abnormality metabolism metabolomic metabolomics non-severe patients predominant purine returned SARS-COV-2 infection serum Spread survival survivor Survivors therapeutic target triggered virus Wuhan, China [DOI] 10.1016/j.heliyon.2022.e10473 [Article Type] Research article
AI-based search for convergently expanding, advantageous mutations in SARS-CoV-2 by focusing on oligonucleotide frequenciesArticle Published on 2022-08-312022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] amino acids candidate changes in expand Focusing Frequency function identify involved Lineage lineages MOST Mutation mutations Neutral occur omicron phylogenetically SARS-CoV-2 SARS-CoV-2 genome sequence Transmission viral genome viral replication virus [DOI] 10.1371/journal.pone.0273860 PMC 바로가기
Integrated microbiome and metabolome analysis reveals the potential therapeutic mechanism of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumoniaArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] 16S rRNA addition affected amino acids Analysis bile acids change China Clinical treatment coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 current Eicosanoids evaluated fatty acids Gut gut microbiota Host Host immune response immune immune function immune response IMPROVE Inflammation lipid metabolism lung tissue mechanism metabolism metabolite metabolome metabolome. metabolomic analysis mice Microbiome modulating patients with COVID-19 performed Pneumonia Qing-Fei-Pai-Du decoction reduce reveal Sequencing serum severity shown significantly Spearman correlation analysis Staphylococcus therapeutic therapeutic effect Treatment was performed [DOI] 10.3389/fcimb.2022.950983 PMC 바로가기
Identification of Potential ACE2-Derived Peptide Mimetics in SARS-CoV-2 Omicron Variant Therapeutics using Computational Approaches전산 접근법을 사용한 SARS-CoV-2 오미크론 변이 치료제의 잠재적 ACE2 유래 펩티드 모방체 식별Article Published on 2022-08-182022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, [키워드] accelerated ACE2 Amino acid amino acids Analysis angiotensin Angiotensin converting enzyme-2 binding binding affinity canonical COVID-19 pandemic dependent on effort event Health Health Organization human infection identification indicated infection rate inhibit inhibition Interaction molecular dynamics Molecular dynamics simulation Mutation omicron path peptide peptides Potential RBD RBDs receptor Receptor binding domain SARS-CoV-2 therapeutic Therapeutics variant variants viral infection VoC WHO World Health Organization [DOI] 10.1021/acs.jpclett.2c01155 PMC 바로가기 [Article Type] Article
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse seraVFLIP-X 스파이크를 생성하는 원형 mRNA 백신 프로토타입은 마우스 혈청에 의한 SARS-CoV-2 변이체의 광범위한 중화를 제공합니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Amino acid amino acid sequence amino acids Antibody titers B.1.1.529 B.1.617.2 balance BNT162b2 boost cellular immune responses cleavage site COVID-19 vaccine Critical D614G detectable Disulfide disulfide bond E484K Evolution of SARS-CoV-2 FIVE flexible glycosylation greater humoral Humoral and cellular immune responses immune responses immunization immunized induce K417N L452R linear linker mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 N501Y neutralization Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers offer pre-fusion producing proline proline substitutions prolines reduced response S-2P SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sequence sera shown spike Spike protein spike trimer stability suggested T478K the spike protein transcript trimer trimeric Vaccine vaccine. Vaccines variant variants variants of concern variants of interest VFLIP virus VOCs VOIs wildtype [DOI] 10.1016/j.antiviral.2022.105370 PMC 바로가기 [Article Type] Article